Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles
Marco Colella, Leonardo Degennaro, Renzo Luisi
Abstract
Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.
Topics & Concepts
Indole testDrug discoveryContinuous flowFlow chemistryFlow (mathematics)ChemistryCombinatorial chemistryComputer scienceNanotechnologyBiochemical engineeringOrganic chemistryMathematicsMaterials scienceEngineeringBiochemistryGeometryInnovative Microfluidic and Catalytic Techniques InnovationNanomaterials for catalytic reactionsCatalytic Cross-Coupling Reactions