Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant <i>cyp51A</i> Promoters in Aspergillus fumigatus
Sanjoy Paul, Paul E. Verweij, Willem J. G. Melchers, W. Scott Moye‐Rowley
Abstract
Aspergillus fumigatus is the most common human filamentous fungal pathogen. Azole drugs are the current therapy of choice for A. fumigatus , but the prevalence of azole resistance is increasing.
Topics & Concepts
Aspergillus fumigatusPromoterVoriconazoleGeneBiologyGene expressionTranscription factorTranscription (linguistics)Molecular biologyGene duplicationGeneticsMicrobiologyAntifungalLinguisticsPhilosophyAntifungal resistance and susceptibilityFungal Infections and StudiesBiochemical and Molecular Research