Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding
Michael Gropp, Courtney L. Klaips, F. Ulrich Hartl
Topics & Concepts
HuntingtinBiologyHuntingtin ProteinProtein aggregationPrion proteinAmyloid (mycology)Cell biologyIn vitroProtein foldingHuntington's diseaseBiophysicsAggresomeBiochemistryMutantDiseaseGeneUbiquitinPathologyBotanyMedicineGenetic Neurodegenerative DiseasesPrion Diseases and Protein MisfoldingMitochondrial Function and Pathology