Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids
Xiaodong Zhang, Haishuang Lin, Liangzhen Dong, Qing Xia
Abstract
Human pluripotent stem cell derived brain organoids offer an unprecedented opportunity for various applications as in vitro model. Currently, human brain organoids as models have been used to understand virus-induced neurotoxicity. Methods: The brain organoids were separately challenged by multiple viruses including influenza viruses (H1N1-WSN and H3N2-HKT68), Enteroviruses (EV68 and EV71) and Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) to investigate the impaired effect of these viruses on human brain development.
Topics & Concepts
OrganoidBiologyInduced pluripotent stem cellNeural stem cellVirusHuman brainVirologyInfluenza A virusApoptosisCell biologyStem cellNeuroscienceGeneEmbryonic stem cellGeneticsinterferon and immune responsesRNA regulation and diseaseRespiratory viral infections research