Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry
Martina Arends, Melanie Weber, Cyrus Papan, Markus Damm, Michał A. Surma, Christopher Spiegel, Minou Djannatian, Shengrong Li, Lisa Connell, Ludger Johannes, Martina Schifferer, Christian Klose, Mikael Simons
Abstract
genes that synthesize most ganglioside species. Our results reveal substantial changes in the ganglioside lipidome during the formation of myelinated nerve fibers. In sum, we provide insights into the CNS ganglioside lipidome with a quantitative and sensitive mass spectrometry method. Since this method is compatible with global lipidomic profiling, it will provide insights into ganglioside function in physiology and pathology.
Topics & Concepts
LipidomeGangliosideLipidomicsChemistryMyelinShotgunGlycolipidBiologyNeuroscienceBiochemistryCentral nervous systemGeneGlycosylation and Glycoproteins ResearchLipid metabolism and disordersCaveolin-1 and cellular processes