Novel drug isolated from mistletoe (1<i>E</i>,4<i>E</i>)-1,7-bis(4-hydroxyphenyl)hepta-1,4-dien-3-one for potential treatment of various cancers: synthesis, pharmacokinetics and pharmacodynamics
Jing Hong, Lin Meng, Peipei Yu, Ceng Zhou, Zhaoyan Zhang, Zhiguo Yu, Feng Qin, Yunli Zhao
Abstract
by using MCF-7 breast cancer models. DHDK showed a dose-dependent relationship without weight reduction, mortality growth inhibition or tissue toxicity. Pharmacokinetics and tissue distribution statistics were determined by LC-ESI-MS/MS. This work provided preliminary data on this natural compound and could open up new prospects for changing related parameters to improve drug efficacy.
Topics & Concepts
CurcuminoidCurcuminPharmacokineticsPharmacologyIn vivoBioavailabilityIn vitroChemistryDrugMedicineBiologyBiochemistryBiotechnologyToxin Mechanisms and ImmunotoxinsCurcumin's Biomedical ApplicationsSynthesis and bioactivity of alkaloids