Carbon Source-Dependent Reprogramming of Anaerobic Metabolism in Staphylococcus aureus
Anne Troitzsch, Vu Van Loi, Karen Methling, Daniela Zühlke, Michael Lalk, Katharina Riedel, Jörg Bernhardt, Eslam Elsayed, Gert Bange, Haike Antelmann, Jan Pané‐Farré
Abstract
Under infection conditions, S. aureus needs to ensure survival when energy production via oxidative phosphorylation is not possible, e.g., either due to the lack of terminal electron acceptors or by the inactivation of components of the respiratory chain. Under these conditions, S. aureus can switch to mixed-acid fermentation to sustain ATP production by substrate-level phosphorylation.
Topics & Concepts
BiologyStaphylococcus aureusMicrobiologyAnaerobic exerciseReprogrammingMetabolismCarbon sourceStaphylococcal infectionsBacteriaBiochemistryGeneticsCellPhysiologyBacterial biofilms and quorum sensingAntimicrobial Resistance in StaphylococcusBacterial Genetics and Biotechnology