Novel peroxosolvates of quinolone antibiotics containing large hydrogen peroxide clusters
Marina A. Kiseleva, Petr V. Prikhodchenko, Andrei V. Churakov
Abstract
Novel class of multicomponent quinolone antibiotics,crystalline hydrogen peroxide adducts of nalidixic acid C12H12N2O3 · H2O2 and ciprofloxacin C17H18F1N3O3 · 5 H2O2, were prepared from highly concentrated hydrogen peroxide, and their structures were determined by X-ray crystallography. The second compound contains decameric H-bonded hydrogen peroxide clusters, which makes this substance one of the richest in hydrogen peroxide among organic peroxosolvates.
Topics & Concepts
ChemistryHydrogen peroxideNalidixic acidAdductQuinoloneHydrogen bondCiprofloxacinPeroxideAntibioticsStereochemistryOrganic chemistryMoleculeBiochemistryCrystallography and molecular interactionsCrystal structures of chemical compoundsPhenothiazines and Benzothiazines Synthesis and Activities