Chronic chikungunya disease (CCD): clinical insights, immunopathogenesis and therapeutic perspectives
Wern Hann Ng, Kleicy Cavalcante Amaral, Émilie Javelle, Suresh Mahalingam
Abstract
Chikungunya virus, an arthropod-borne pathogen is recognized by the World Health Organization as a top priority Emerging Infectious Disease and is ranked fourth in public health needs according to the Coalition for Epidemic Preparedness Innovations. Despite its substantial impact, as evidenced by an annual estimate of 120 274 disability-adjusted life years, our understanding of the chronic aspects of chikungunya disease remains limited. This review focuses on chronic chikungunya disease, emphasizing its clinical manifestations, immunopathogenesis, therapeutic options and disease burden.
Topics & Concepts
ChikungunyaDiseasePublic healthChikungunya feverPreparednessMedicineInfectious disease (medical specialty)Emerging infectious diseaseVirusIntensive care medicineImmunologyPolitical sciencePathologyLawMosquito-borne diseases and controlStudies on Chitinases and ChitosanasesMalaria Research and Control