Isolation of pancreatic microbiota from cystic precursors of pancreatic cancer with intracellular growth and DNA damaging properties
Asif Halimi, Giorgio Gabarrini, Michał J. Sobkowiak, Zeeshan Ateeb, Haleh Davanian, Rogier Gaiser, Urban Arnelo, Roberto Valente, Alicia Y. W. Wong, Carlos Fernández Moro, Marco Del Chiaro, Volkan Özenci, Margaret Chen
Abstract
co-culture models. Pathogenic properties include intracellular survival capability, cell death induction, or causing DNA double-strand breaks in the surviving cells resembling genotoxic effects. This study provides new insights into the role of the pancreatic microbiota in the intriguing link between pancreatic cystic lesions and cancer.
Topics & Concepts
BiologyPancreatic cancerGammaproteobacteriaMicrobiomeMicrobiologyPancreasBacteriaCancerCancer researchBioinformaticsGenetics16S ribosomal RNABiochemistryPancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentInfections and bacterial resistance