Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT
Shengbo Zhang, Hannah D. Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J. Kueh, Daniel V. Brown, Wang Cao, Nicolas Jacquelot, Angela D’Amico, Andrew M. Lew, Yifan Zhan, Christopher J. Tonkin, Jóse A. Villadangos, Gordon K. Smyth, Michaël Chopin, Stephen L. Nutt
Abstract
Our study reveals DC-SCRIPT to be a critical component of the gene regulatory program shaping the functional attributes of cDC1s.
Topics & Concepts
Dendritic cellTranscription factorCell fate determinationFunction (biology)Cell biologyBiologyKey (lock)ImmunologyImmune systemGeneticsEcologyGeneImmunotherapy and Immune ResponsesT-cell and B-cell Immunologyvaccines and immunoinformatics approaches