Glabridin Plays Dual Action to Augment the Efficacy and Attenuate the Hepatotoxicity of Methotrexate in Arthritic Rats
Ashish Dogra, Dilpreet Kour, Mahir Bhardwaj, Sumit Dhiman, Amit Kumar, Bhavna Vij, Ajay Kumar, Utpal Nandi
Abstract
the inhibition of inflammation and oxidative stress. Further research should be performed to develop glabridin as a phytotherapeutics for the improved efficacy and better tolerability of MTX at the reduced dose level of MTX.
Topics & Concepts
PharmacologyMethotrexateGlutathioneOxidative stressMalondialdehydeRheumatoid arthritisChemistryMedicineBiochemistryImmunologyEnzymePharmacological Effects of Natural CompoundsGinseng Biological Effects and ApplicationsRheumatoid Arthritis Research and Therapies