A Dual-Protein Cascade Reaction for the Regioselective Synthesis of Quinoxalines
Fengxi Li, Xuyong Tang, Yaning Xu, Chunyu Wang, Zhi Wang, Zhengqiang Li, Lei Wang
Abstract
In this work, an efficient dual-protein (lipase and hemoglobin) system was successfully constructed for the regioselective synthesis of quinoxalines in water. A set of quinoxalines were obtained in high yields under optimal reaction conditions. This dual-protein method exhibited a regioselectivity higher than those of previously reported methods. This study not only provides a green and mild strategy for the synthesis of quinoxalines but also expands the application of lipase and hemoglobin in organic synthesis.
Topics & Concepts
RegioselectivityChemistryLipaseCombinatorial chemistryDual (grammatical number)CascadeReaction conditionsOrganic chemistryCatalysisEnzymeChromatographyArtLiteratureSynthesis and Biological EvaluationCO2 Reduction Techniques and Catalysts