The dysfunctional Wnt pathway down-regulates MLH1/SET expression and promotes microsatellite instability and immunotherapy response in colorectal cancer
Jiyan Wang, Tao He, Qingle Gao, Hongkai Chang, Xintong Dai, Juze Yang, Shuangping Liu, Shuai Zhang, Changliang Shan, Chunze Zhang
Topics & Concepts
MLH1Microsatellite instabilityColorectal cancerWnt signaling pathwayDysfunctional familyCancer researchImmunotherapyCancerBiologyMedicineMicrosatelliteGeneticsGeneDNA mismatch repairClinical psychologyAlleleGenetic factors in colorectal cancerCancer-related molecular mechanisms researchWnt/β-catenin signaling in development and cancer