Enhanced in vitro tumoricidal effects of 5-Fluorouracil, thymoquinone, and active vitamin D3 triple therapy against colon cancer cells by attenuating the PI3K/AKT/mTOR pathway
Shakir Idris, Bassem Refaat, Riyad A. Almaimani, Hussain G. Ahmed, Jawwad Ahmad, Mai Alhadrami, Mahmoud Zaki El-Readi, Mohamed Elzubier, Haneen A.A. Alaufi, Badriah Al-Amin, Ahmad Al-Ghamdi, Fayez S. Bahwerth, Faisal Minshawi, Saeed Kabrah, Akhmed Aslam
Topics & Concepts
ThymoquinonePI3K/AKT/mTOR pathwayProtein kinase BPTENApoptosisCancer researchMedicinePharmacologyChemistryBiochemistryAntioxidantNigella sativa pharmacological applicationsChemotherapy-induced organ toxicity mitigationMultiple and Secondary Primary Cancers