A Survey of <i>Helicobacter pylori</i> Antibiotic-Resistant Genotypes and Strain Lineages by Whole-Genome Sequencing in China
Yan Zhou, Zishao Zhong, Shengjuan Hu, Jing Wang, Yanhong Deng, Ximei Li, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaofei Li, Hao Qian, Jun Liu, Tian Sang, Bo Yang, Feihu Bai
Abstract
Antibiotic resistance is the most important factor leading to failed Helicobacter pylori eradication therapy, and personalized treatment based on antibiotic susceptibility is becoming increasingly important. To strengthen the understanding of antibiotic genotypic resistance of H. pylori and identify new antibiotic resistance loci, in this study, we identified phenotypic resistance information for 60 clinical isolates and compared the concordance of phenotypic and genotypic resistance using whole-genome sequencing (WGS).
Topics & Concepts
Antibiotic resistanceBiologyGenotypeGeneticsHelicobacter pyloriLevofloxacinClarithromycinDrug resistanceMicrobiologyAntibioticsGeneHelicobacter pylori-related gastroenterology studiesVeterinary medicine and infectious diseasesMycobacterium research and diagnosis