Analogous Metabolic Decoupling in Pseudomonas putida and Comamonas testosteroni Implies Energetic Bypass to Facilitate Gluconeogenic Growth
Rebecca A. Wilkes, Jacob Waldbauer, Ludmilla Aristilde
Abstract
Glycolytic metabolism of sugars is extensively studied in the Proteobacteria , but gluconeogenic carbon sources (e.g., organic acids, amino acids, aromatics) that feed into the tricarboxylic acid (TCA) cycle are widely reported to produce a fast-growth phenotype, particularly in species with biotechnological relevance. Much remains unknown about the importance of glycolysis-associated pathways in the metabolism of gluconeogenic carbon substrates.
Topics & Concepts
Pseudomonas putidaMetabolic pathwayBiochemistryMetabolic flux analysisOxidative phosphorylationBiologyCitric acid cycleComamonas testosteroniFlux (metallurgy)Metabolic engineeringGlycolysisGluconeogenesisMetabolismMetabolomicsChemistryEnzymeBioinformaticsOrganic chemistryMicrobial Metabolic Engineering and BioproductionMicrobial metabolism and enzyme functionFungal and yeast genetics research