Innate Lymphoid Cells and Their Role in the Immune Response to Infections
Marek Fol, Wojciech Karpik, Agnieszka Zabłotni, Jakub Kulesza, Ewelina Kulesza, Magdalena Godkowicz, Magdalena Druszczyńska
Abstract
Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells that act as tissue-resident sentinels against infections. Numerous studies have elucidated the characteristics of ILC subgroups, but the mechanisms controlling protective or pathological responses to pathogens still need to be better understood. This review summarizes the functions of ILCs in the immunology of infections caused by different intracellular and extracellular pathogens and discusses their possible therapeutic potential.