Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis
Yun Zhang, Joana Liu Donaher, Sunny Das, Xin Li, Ferenc Reinhardt, Jordan A. Krall, Arthur W. Lambert, Prathapan Thiru, Heather R. Keys, Mehreen Ali Khan, Matan Hofree, Molly M. Wilson, Ozlem Yedier-Bayram, Nathan A. Lack, Tamer T. Önder, Tugba Bagcı-Önder, Michael Tyler, Itay Tirosh, Aviv Regev, Jacqueline A. Lees, Robert A. Weinberg
Topics & Concepts
ChromatinEpigeneticsPRC2BiologyPhenotypeEpithelial–mesenchymal transitionMetastasisCancer researchCRISPRCancerGeneticsCell biologyEZH2DNAGeneCancer Genomics and DiagnosticsEpigenetics and DNA MethylationCancer Cells and Metastasis