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Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

Yun Zhang, Joana Liu Donaher, Sunny Das, Xin Li, Ferenc Reinhardt, Jordan A. Krall, Arthur W. Lambert, Prathapan Thiru, Heather R. Keys, Mehreen Ali Khan, Matan Hofree, Molly M. Wilson, Ozlem Yedier-Bayram, Nathan A. Lack, Tamer T. Önder, Tugba Bagcı-Önder, Michael Tyler, Itay Tirosh, Aviv Regev, Jacqueline A. Lees, Robert A. Weinberg

2022Nature Cell Biology128 citationsDOIOpen Access PDF

Topics & Concepts

ChromatinEpigeneticsPRC2BiologyPhenotypeEpithelial–mesenchymal transitionMetastasisCancer researchCRISPRCancerGeneticsCell biologyEZH2DNAGeneCancer Genomics and DiagnosticsEpigenetics and DNA MethylationCancer Cells and Metastasis
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis | Litcius