LRRC4 mediates the formation of circular RNA CD44 to inhibit GBM cell proliferation
Jianbo Feng, Xing Ren, Haijuan Fu, Di Li, Xiguang Chen, Xuyu Zu, Qing Liu, Minghua Wu
Abstract
. Mechanistically, circCD44 could regulate the expression of SMAD6 via sponging miR-326 and miR-330-5p involved in the progression of GBM. Thus, the LRRC4/SAM68/circCD44/miR-326/miR-330-5p/SMAD6 signaling axis could be a potential target for GBM treatment.
Topics & Concepts
CD44Cancer researchCircular RNAGlioblastomaCell growthmicroRNABiologyIn vivoDownregulation and upregulationCell biologyChemistryIn vitroGeneGeneticsCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research