A hybrid ocular delivery system of cyclosporine-A comprising nanomicelle-laden polymeric inserts with improved efficacy and tolerability
Eleonora Terreni, Patrizia Chetoni, Susi Burgalassi, Silvia Tampucci, Erica Zucchetti, Edwin Chipala, Raid G. Alany, Ali A. Al-Kinani, Daniela Monti
Abstract
= 0.0187). The ability of F3 to delay the elimination of the drug from the precorneal area is particularly desirable when treating dry eye syndrome. Furthermore, F3 did not induce ocular discomfort, a typical characteristic of solid ocular inserts, including commercially available ones.
Topics & Concepts
TolerabilityPharmacokineticsChemistryDrug deliveryIn vivoIrritationChromatographyEye irritationDosage formPharmacologyDelivery systemBiomedical engineeringMedicineOrganic chemistryAdverse effectBiotechnologyImmunologyBiologyAdvanced Drug Delivery SystemsOcular Surface and Contact LensAdvancements in Transdermal Drug Delivery