Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation
Sichuan Xiang, Ding Huang, Qiaolin He, Jie Li, Kin Yip Tam, Shaolin Zhang, Yun He
Topics & Concepts
Lactate dehydrogenase AGlycolysisLactate dehydrogenaseChemistryBiochemistryKinasePyruvate dehydrogenase complexCitric acid cycleVirtual screeningDehydrogenaseCancer cellPyruvate kinaseHigh-throughput screeningEnzymeDrug discoveryCancerBiologyGeneticsCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchMetabolism, Diabetes, and Cancer