Application of the LADA Strategy for the Synthesis of Unnatural Amino Acids through 1,2-Aryl Migration of Allylic Alcohols
Pannan Miao, Mengyao Zhang, Zhuojun Ni, Qi Chen, Zhankui Sun
Abstract
Unnatural amino acids are versatile building blocks. Herein, we report the application of the LADA strategy for the direct synthesis of unnatural amino acids through 1,2-aryl migration of allylic alcohols. This reaction proceeds under mild conditions, tolerates diverse functionalities, and works smoothly on different thiols.
Topics & Concepts
ChemistryAllylic rearrangementAmino acidArylCombinatorial chemistryOrganic chemistryBiochemistryCatalysisAlkylChemical Synthesis and AnalysisAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions