B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-catalyzed β-C(sp<sup>3</sup>)–H alkylation of tertiary amines with 2-aryl-3<i>H</i>-indol-3-ones
Changpeng Zou, Tao Ma, Xiu‐Xiu Qiao, Xixi Wu, Ganpeng Li, Yonghui He, Xiaojing Zhao
Abstract
-catalyzed borrowing hydrogen strategy. According to the experimental results, a possible catalytic cycle has been proposed to rationalize the process of this reaction. Notably, the β-C-H alkylation of amines is external oxidant- and transition-metal-free, which makes a significant contribution to promoting economical chemical synthesis.
Topics & Concepts
AlkylationArylCatalysisMedicinal chemistryChemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistryRadical Photochemical Reactions