Discovery of new pyrimidopyrrolizine/indolizine-based derivatives as P-glycoprotein inhibitors: Design, synthesis, cytotoxicity, and MDR reversal activities
Ahmed M. Shawky, Ashraf N. Abdalla, Nashwa A. Ibrahim, Mohammed A. S. Abourehab, Ahmed M. Gouda
Topics & Concepts
ChemistryCytotoxicityP-glycoproteinPharmacologyCytotoxic T cellLead compoundMultiple drug resistanceEffluxDocking (animal)IC50StereochemistryCombinatorial chemistryIn vitroBiochemistryAntibioticsMedicineNursingDrug Transport and Resistance MechanismsSynthesis and Reactivity of HeterocyclesCancer therapeutics and mechanisms