Targeted Molecular Construct for Bioorthogonal Theranostics of PD-L1-Expressing Cancer Cells
Shiao Y. Chow, Asier Unciti‐Broceta
Abstract
by click-to-release activation of prodrugs and selective killing of PD-L1-expressing breast cancer cells, offering a new multimodal approach to "track-&-treat" malignant cells that are capable of evading the immune system.
Topics & Concepts
Bioorthogonal chemistryCancer cellChemistryClick chemistryTetrazineCancer researchLigand (biochemistry)ConjugateCancerBiochemistryBiologyCombinatorial chemistryReceptorMathematical analysisOrganic chemistryGeneticsMathematicsClick Chemistry and ApplicationsCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies Research