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Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

Nga Nguyen, Kuo Du, Jephte Y. Akakpo, David S. Umbaugh, Hartmut Jaeschke, Anup Ramachandran

2020Toxicology Letters68 citationsDOIOpen Access PDF

Topics & Concepts

CytosolTerminal (telecommunication)AdductChemistrySuperoxidec-junMitochondrionKinaseAcetaminophenBiochemistryEnzymeGeneComputer networkComputer scienceOrganic chemistryTranscription factorDrug-Induced Hepatotoxicity and ProtectionMalaria Research and ControlMetabolomics and Mass Spectrometry Studies
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice | Litcius