Disease trends after <i>Helicobacter pylori</i> eradication based on Japanese nationwide claims and the health check-up database
Kazuhiro Mizukami, Kentaro Sugano, Tomomi Takeshima, Kazunari Murakami
Abstract
BACKGROUND: eradication therapy. AIM: eradication and to comprehensively assess its effects. METHODS: year after the year of eradication) based on the age category and calendar year and month. Changes in body mass index and proportion of patients with metabolic syndrome (MS) were examined before and after eradication. RESULTS: < 0.01%-0.05%). The incidence of IBD and prevalence of allergic disease were also higher after eradication. In contrast, the incidence of gastric and duodenal ulcers and gastritis was reduced after eradication. In patients with at least one entry of health check-up data (1701111 patients), the percentage of patients with MS showed a slight increase following eradication (11.0% in the year of eradication and 12.2% after 5 years). CONCLUSION: eradication therapy reduces peptic ulcers and gastritis; however, it is associated with increased incidence of several other chronic diseases.