A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix
Ivan Boldyrev, V. P. Shendrikov, A. G. Vostrova, Е. Л. Водовозова
Abstract
The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient vaccine assembly, protects the mRNA from premature degradation, and promotes the release of the nucleic acid into the cytoplasm for its further processing after endocytosis. The present work describes a simple and economical method for the synthesis of the ALC-0315 lipid, which can be taken advantage of in mRNA vaccine production.
Topics & Concepts
Bioorganic chemistryKey (lock)ChemistryComponent (thermodynamics)Matrix (chemical analysis)Computational biologyBiochemistryPhysicsBiologyEnzymeEcologyChromatographyQuantum mechanicsSARS-CoV-2 and COVID-19 ResearchRNA Interference and Gene DeliveryViral Infections and Immunology Research