Surface specifically modified NK-92 cells with CD56 antibody conjugated superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles for magnetic targeting immunotherapy of solid tumors
Songbo Zhao, Jiazhi Duan, Yalin Lou, Ruyun Gao, Shanshan Yang, Piming Wang, Chunhua Wang, Lin Han, Minghuan Li, Chunhong Ma, Xiaohong Liang, Hong Liu, Yuanhua Sang, Lifen Gao
Abstract
under external magnetic field guidance and efficiently inhibit tumor growth. These functionalized NK cells represent a novel approach for solid tumor therapy and may provide a promising modality for cancer interventions in the future.
Topics & Concepts
ImmunotherapyCancer researchCancer immunotherapyIn vivoMaterials scienceCytotoxicityAntibodyConjugated systemSuperparamagnetismMagnetic nanoparticlesNanotechnologyMedicineNanoparticleImmunologyIn vitroImmune systemBiologyMagnetic fieldPolymerBiochemistryMagnetizationBiotechnologyComposite materialQuantum mechanicsPhysicsImmune Cell Function and InteractionCAR-T cell therapy researchNanoparticle-Based Drug Delivery