Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus
Jeffrey Downey, Haley E. Randolph, Erwan Pernet, Kim A. Tran, Shabaana A. Khader, Irah L. King, Luis B. Barreiro, Maziar Divangahi
Abstract
mice after IAV infection. Collectively, these results demonstrate a key role for CypD in NK cell-mediated disease tolerance.
Topics & Concepts
BiologyImmune systemImmunologyInfluenza A virusVirusChemokineCell biologySignaling Pathways in DiseaseImmune Cell Function and InteractionCytokine Signaling Pathways and Interactions