Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect
Lama Al‐Qusairi, Mohammed Z. Ferdaus, Truyen D. Pham, Dimin Li, P. Richard Grimm, Ava M. Zapf, Delaney C. Abood, Seyed Mohammad Ebrahim Tahaei, Eric Delpire, Susan M. Wall, Paul A. Welling
Abstract
Dietary anions profoundly impact K + homeostasis. Here, we found that a K + -rich diet, containing [Formula: see text] as the counteranion, enhances the electrogenic K + excretory machinery, epithelial Na + channels, and renal outer medullary K + channels, much more than a high-KCl diet. It also uniquely induces KCC3a and pendrin, in B-intercalated cells, providing an electroneutral KHCO 3 secretion pathway. These findings reveal new K + balance mechanisms that drive adaption to alkaline and K + -rich foods, which should guide new treatment strategies for K + disorders.