STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia
Giulio Morozzi, Julian Rothen, Gauthier Toussaint, Katrina de Lange, Katrin Westritschnig, Arno Doelemeyer, Vanessa Pitiot Ueberschlag, Peter Kahle, Christian Lambert, Michael Obrecht, Nicolau Beckmann, Veronique Ritter, Moh Panesar, Daniela Stauffer, Isabelle Garnier, Matthias Mueller, Danilo Guerini, Caroline Gubser Keller, Judith Knehr, Guglielmo Roma, Michael Bidinosti, Sophie Brachat, Frédéric Morvan, Mara Fornaro
Abstract
. Taking together, these data highlight a previously unrecognized role of STING in the regulation of nerve regeneration.
Topics & Concepts
Sciatic nerveRegeneration (biology)StingStimulator of interferon genesAxonPeripheral nerve injuryMicrogliaNerve growth factorCell biologyMyelinPeripheral nervous systemNerve injuryCrush injuryReceptorDownregulation and upregulationSciatic nerve injuryImmunologyMedicineChemistryBiologyAnatomyNeuroscienceInflammationInternal medicineInnate immune systemCentral nervous systemSurgeryBiochemistryAerospace engineeringGeneEngineeringinterferon and immune responsesImmune Response and InflammationNeuroinflammation and Neurodegeneration Mechanisms