Mesenchymal Stem Cells Mediated Drug Delivery in Tumor-Targeted Therapy
Mengying Xie, Lei Tao, Ziqi Zhang, Wei Wang
Abstract
Mesenchymal Stem Cells (MSCs) possess unique properties that make them potential carriers for cancer therapy. MSCs have been documented to have low immunogenicity, positive safety in clinical trials, and the ability to selectively perform homing to inflammation and tumor sites. This review aims to introduce tumor tropism mechanism and effects of MSCs on tumor cells, and give an overview of MSCs in delivering gene therapeutic agents, oncolytic viruses and chemotherapeutics, as well as the application of MSCs-derived exosomes in tumor-targeted therapy.
Topics & Concepts
Mesenchymal stem cellHoming (biology)MicrovesiclesImmunogenicityOncolytic virusCancer researchMedicineTropismDrugGenetic enhancementDrug deliveryTumor cellsImmunologyImmune systemBiologyPathologyPharmacologyVirusmicroRNAChemistryGeneBiochemistryOrganic chemistryEcologyRNA Interference and Gene DeliveryMesenchymal stem cell researchVirus-based gene therapy research