Development and evaluation of a pH-responsive and water-soluble drug delivery system based on smart polymer coating of graphene nanosheets: an <i>in silico</i> study
Abutaleb Alinejad, Heidar Raissi, Hassan Hashemzadeh
Abstract
have been established. Furthermore, evaluating the dynamic behavior of the designed systems in water solution shows that the polymer in physiological pH rapidly adsorbed on the drug-carrier complex. However, at acidic pH, it is quickly desorbed from the carrier surface and the G-DOX complex can be exposed to cancer cells. The obtained results of the present research may be used in future experimental work to design smart DDSs.
Topics & Concepts
GrapheneCoatingIn silicoDrug deliveryPolymerMaterials scienceDrugChemical engineeringSmart polymerNanotechnologyChemistryComposite materialPharmacologyMedicineBiochemistryEngineeringGeneGraphene and Nanomaterials ApplicationsNanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applications