Orthogonal <i>sp</i> <sup> <i>3</i> </sup> ‐Ge/B Bimetallic Modules: Enantioselective Construction and Enantiospecific Cross‐Coupling
Mengyu Xu, Weitao Jiang, Ming‐Zhi Xia, Zi‐Long An, Xiu‐Ying Xie, Bin Xiao
Abstract
-Ge/B bimetallic modules were successfully synthesized via an enantioselective copper-catalyzed hydroboration of carbagermatrane (Ge)-containing alkenes. Orthogonal cross-coupling selectivity under different Pd-catalyzed conditions was achieved in an enantiospecific manner. Notably, the chiral secondary Ge exhibited a remarkable transmetallation ability prior to primary or secondary Bpin. The effectiveness of this Ge/B bimetallic strategy was further demonstrated through the development of new functional small molecules with Aggregation-Induced Emission (AIE) and Circularly Polarized Luminescence (CPL) performance. This represents the first successful example of synthesis of enantioenriched alkylgermanium reagents that permit enantiospecific cross-coupling reactions.