Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia
Jiaquan Lin, Xiaoyan Shao, Tianshu Shi, Haosheng Wang, Pan Zhang, Yining Zhou, Liu Na, Yi He, Depeng Fang, Yong Shi, Yuze Ma, Bin Liu, Wang Gong, Wenshu Wu, Rui Peng, Chengzhi Wang, Tao Shen, Zhuoying Jiang, Yu Ben, Jianghui Qin, Zhihong Xu, Xiang Chen, Qing Jiang, Guo Baosheng
Topics & Concepts
Skeletal muscleMyokineMicrogliaMicrovesiclesExtracellularMyogenesisMedicineExtracellular vesiclesHomeostasisExtracellular vesicleEndocrinologySecretionNeuroscienceDiseasePhysical exerciseInternal medicineCell biologyNeuroinflammationCentral nervous systemExosomeBiologyCognitive declinePinocytosisInflammationMediatorIntracellularEndocrine systemMyelinMyocyteGlucose homeostasisExtracellular vesicles in diseaseNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments