Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers
Laura Braconi, Silvia Dei, Marialessandra Contino, Chiara Riganti, Gianluca Bartolucci, Dina Manetti, María Novella Romanelli, Maria Grazia Perrone, Nicola Antonio Colabufo, Stefano Guglielmo, Elisabetta Teodori
Topics & Concepts
ChemistryOxadiazoleTetrazoleAmideEffluxLead compoundStereochemistryMultiple drug resistanceP-glycoproteinIn vitroTransporterPharmacologyCombinatorial chemistryBiochemistryOrganic chemistryGeneMedicineAntibioticsCancer therapeutics and mechanismsDrug Transport and Resistance MechanismsDNA and Nucleic Acid Chemistry