Pseudomonas aeruginosa Polynucleotide Phosphorylase Controls Tolerance to Aminoglycoside Antibiotics by Regulating the MexXY Multidrug Efflux Pump
Zheng Fan, Xiaolei Pan, Dan Wang, Ronghao Chen, Tongtong Fu, Baopeng Yang, Yongxin Jin, Fang Bai, Zhihui Cheng, Weihui Wu
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen that shows high intrinsic resistance to a variety of antibiotics. The MexX-MexY-OprM efflux pump plays an important role in bacterial resistance to aminoglycoside antibiotics.
Topics & Concepts
EffluxPseudomonas aeruginosaAminoglycosideMicrobiologyAntibioticsPolynucleotide phosphorylaseBiologyMultiple drug resistanceBacteriaBiochemistryGeneticsEnzymePurine nucleoside phosphorylasePurineAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyBacteriophages and microbial interactions