Ruthenium-Catalyzed Monoselective C–H Methylation and <i>d</i><sub>3</sub>-Methylation of Arenes
Ashley Hogg, Matthew Wheatley, Pablo Domingo‐Legarda, Asier Carral‐Menoyo, Naomi Cottam, Igor Larrosa
Abstract
-methylation in addition to the late-stage functionalization of pharmaceutically active compounds. Detailed kinetic studies indicate the rate-limiting in situ formation of MeI is integral to the observed reactivity.
Topics & Concepts
RutheniumMethylationCatalysisChemistryMedicinal chemistryOrganic chemistryBiochemistryGeneChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisEpigenetics and DNA Methylation