The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin
Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet‐Greif, Jean‐Philippe Nougayrède, Éric Oswald, Priscilla Branchu
Abstract
and the production of colibactin. Interestingly, PPK is a multifunctional player in bacterial virulence and stress responses and has been proposed as a new target for developing antimicrobial medicine. We observed inhibition of colibactin production by using a previously identified PPK inhibitor (i.e., mesalamine, an anti-inflammatory drug commonly prescribed for inflammatory bowel diseases). These data brought us a new perspective on the regulatory network of colibactin production and provided us a clue for the development of anticolibactin strategies for CRC treatment/prophylaxis.
Topics & Concepts
Escherichia coliKinaseDNA damagePolyphosphateBiologyDNAColorectal cancerInflammationMicrobiologyCancer researchGeneCancerCell biologyGeneticsBiochemistryImmunologyPhosphateCoagulation, Bradykinin, Polyphosphates, and AngioedemaPI3K/AKT/mTOR signaling in cancerCancer Mechanisms and Therapy