Role of the nervous system in cancers: a review
Huan Wang, Qiming Zheng, Zeyi Lu, Liya Wang, Lifeng Ding, Liqun Xia, Hao Zhang, Mingchao Wang, Yi-Cheng Chen, Gonghui Li
Abstract
Nerves are important pathological elements of the microenvironment of tumors, including those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent studies have associated perineural invasion with tumor progression and poor outcomes. In turn, tumors drive the reprogramming of neurons to recruit new nerve fibers. Therefore, the crosstalk between nerves and tumors is the hot topic and trend in current cancer investigations. Herein, we reviewed recent studies presenting direct supporting evidences for a better understanding of nerve-tumor interactions.
Topics & Concepts
CrosstalkMedicinePathologicalTumor microenvironmentProstatePerineural invasionPancreatic cancerNervous systemProstate cancerHead and neckPathologyCancerInternal medicineSurgeryPhysicsOpticsPsychiatryCancer, Stress, Anesthesia, and Immune ResponseVagus Nerve Stimulation ResearchBrain Metastases and Treatment