A pumpless microfluidic co-culture system to model the effects of shear flow on biological barriers
Marsel Lino, Henrik Persson, Mohammad Paknahad, Alisa Ugodnikov, Morvarid Farhang Ghahremani, Lily E Takeuchi, Oleg Chebotarev, Caleb Horst, Craig A. Simmons
Abstract
Organ-on-a-chip modeling of biological barriers, like the vascular endothelium, blood-brain barrier, and gut, is enabled by VitroFlo, a co-culture microfluidic device that generates physiological unidirectional shear flow without the need for pumps.
Topics & Concepts
Microscale chemistryMicrofluidicsNanotechnologyDrug deliveryKey (lock)Biochemical engineeringCell biologyBiologyEngineeringMaterials scienceEcologyPsychologyMathematics education3D Printing in Biomedical Research