Reprogramming of Energy Metabolism in Kidney Disease
Prabhleen Singh
Abstract
Kidney tubules have high metabolic activity to support solute transport and other cellular functions. Energy generation in the kidney is largely dependent on mitochondrial oxidative phosphorylation, particularly in the proximal tubules. Important alterations in the pathways of energy generation and cellular metabolism have been identified in early and late stages of kidney disease. This review provides a succinct summary of the current literature on the central role of energy metabolism in the pathophysiology of acute and chronic kidney disease.
Topics & Concepts
KidneyMedicineKidney diseaseEnergy metabolismMitochondrionPathophysiologyMetabolismDiseaseOxidative phosphorylationReprogrammingCellular metabolismInternal medicineEndocrinologyCell biologyBiologyCellBiochemistryDiet and metabolism studiesDialysis and Renal Disease ManagementMetabolism and Genetic Disorders