Porin deficiency or plasmid copy number increase mediated carbapenem-resistant <i>Escherichia coli</i> resistance evolution
Guoxiu Xiang, Zhiwei Zhao, Shebin Zhang, Yimei Cai, Yuting He, Jianming Zeng, Chen Cha, Bin Huang
Abstract
D140Y (GAT→TAT) mutation. Bacterial hosts and conjugative plasmids can undergo resistance evolution under certain concentrations of antimicrobial pressure by reducing the expression of outer membrane proteins or increasing plasmid copy numbers.
Topics & Concepts
Escherichia coliPlasmidMicrobiologyBiologyCarbapenemPorinEscherichia coli ProteinsGeneticsVirologyGeneBacterial outer membraneAntibioticsAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyEscherichia coli research studies