Quinoline‐fused both non‐peripheral and peripheral Zn<sup>II</sup>and Mg<sup>II</sup>phthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies
Halise Yalazan, Burak Tüzün, Didem Akkaya, Burak Barut, Halıt Kantekın, Sermet Yıldırmış
Abstract
Quinoline‐fused Zn II ( ZnPc p /ZnPc np ) and Mg II ( MgPc p /MgPc np ) phthalocyanines with four 4‐methylquinolin‐2‐ol ( 1 ) at non‐peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization of phthalonitrile derivatives ( CN p /CN np ) in the presence of zinc (II) and magnesium (II) metal ions in this study. After synthesis and characterization processes, anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and non‐peripheral Zn II and Mg II phthalocyanines were investigated. The inhibitory effects of metallated phthalocyanines on acetylcholinesterase, butyrylcholinesterase, and α‐glucosidase enzymes were tested by spectrophotometric method. Theoretical methods are used to compare both the chemical and biological activities of the studied phthalonitrile derivatives and metallated phthalocyanine compounds.