Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD
Rodrigo Manjarín, Kayla Dillard, Morgan Coffin, Gabriella V. Hernandez, Victoria Smith, Trista Noland-Lidell, Tanvi R. Gehani, Hayden J. Smart, Kevin Wheeler, Kimberly A. Sprayberry, Mark S. Edwards, Rob Fanter, Hunter Glanz, Chad E. Immoos, Tasha M. Santiago-Rodríguez, Jason M. Blank, Douglas G. Burrin, Brian D. Piccolo, Mohammed Abo-Ismail, Michael R. La Frano, Magdalena Maj
Abstract
Bile acid homeostasis and signaling is disrupted in NAFLD and may play a central role in the development of the disease. However, there are no studies addressing the impact of diet on bile acid metabolism in patients with NAFLD. In juvenile Iberian pigs, we show that fatty acid composition in high-fat high-fructose diets affects BA levels in liver, plasma, and colon but these changes were not associated with the severity of the disease.