Design and optimization of metformin-loaded solid lipid nanoparticles for neuroprotective effects in a rat model of diffuse traumatic brain injury: A biochemical, behavioral, and histological study
Hossein Ebrahimi, Sajjad Kazem Nezhad, Ali Farmoudeh, Amirhossein Babaei, Pedram Ebrahimnejad, Esmaeil Akbari, Ali Siahposht-Khachaki
Topics & Concepts
NeuroprotectionTraumatic brain injuryBlood–brain barrierMedicinePharmacologyMetforminOxidative stressZeta potentialNeuroinflammationIn vivoSolid lipid nanoparticleDrug deliveryInflammationAnesthesiaDrugCentral nervous systemChemistryDiabetes mellitusInternal medicineEndocrinologyBiologyMaterials scienceNanoparticleNanotechnologyPsychiatryOrganic chemistryBiotechnologyAdvanced Drug Delivery SystemsRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery