2′-<i>O</i>-Trifluoromethylated RNA – a powerful modification for RNA chemistry and NMR spectroscopy
Maximilian Himmelstoß, Kevin Erharter, Eva Renard, Eric Ennifar, Christoph Kreutz, Ronald Micura
Abstract
group that well integrates into the minor groove. The new label carries high potential to outcompete currently applied fluorine labels for nucleic acid NMR spectroscopy because of its significantly advanced performance.
Topics & Concepts
ChemistryNuclear magnetic resonance spectroscopyRNASpectroscopyComputational chemistryOrganic chemistryPhysicsBiochemistryGeneQuantum mechanicsFluorine in Organic ChemistryRNA modifications and cancerInorganic Fluorides and Related Compounds