Collecting duct water permeability inhibition by EGF is associated with decreased cAMP, PKA activity, and AQP2 phosphorylation at Ser<sup>269</sup>
Chung‐Lin Chou, Kavee Limbutara, Anika R. Kao, Jevin Z. Clark, Ellen H. Nein, Viswanathan Raghuram, Mark A. Knepper
Abstract
The authors used native rat collecting ducts to show that inhibition of vasopressin-stimulated water permeability by epidermal growth factor involves a reduction of aquaporin 2 phosphorylation at Ser 269 , a consequence of reduced cAMP production and PKA activity.
Topics & Concepts
PhosphorylationAquaporin 2VasopressinProtein kinase AEpidermal growth factorProtein phosphorylationKinaseChemistryIntracellularCell biologyEndocrinologyInternal medicineBiologyBiochemistryReceptorMedicineMechanical engineeringEngineeringWater channelInletIon Transport and Channel RegulationNeuroendocrine regulation and behaviorElectrolyte and hormonal disorders